GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs3829251 | 1 | rs11233977 | chr11:71221605 | KRTAP5-10 | chr11:71276609-71277666:+ | 0.2 | 3.85 | 0.000136 | Vitamin D levels |
| BLCA | cis | rs3829251 | 1 | rs11234027 | chr11:71234107 | KRTAP5-10 | chr11:71276609-71277666:+ | 0.2 | 3.92 | 0.000105 | Vitamin D levels |
| BLCA | cis | rs11723261 | 1 | rs11248009 | chr4:220149 | ZNF718 | chr4:53272-156488:+ | 0.36 | 4.68 | 3.93E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs11248013 | chr4:311425 | ZNF718 | chr4:53272-156488:+ | 0.35 | 4.65 | 4.58E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs1109501 | 1 | rs11249502 | chr4:71341161 | AMTN | chr4:71384298-71398459:+ | 0.24 | 3.97 | 8.76E-5 | Alcoholism (heaviness of drinking) |
| BLCA | cis | rs9815354 | 1 | rs1125203 | chr3:41760895 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.9 | 9.78E-21 | Diastolic blood pressure |
| BLCA | cis | rs6951245 | 1 | rs113066613 | chr7:1094128 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.41 | 1.32E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs113146460 | chr7:1105164 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.48 | 1.0E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs7129220 | 1 | rs113231679 | chr11:10351345 | IPO7 | chr11:9406169-9469673:+ | 0.27 | 3.99 | 7.85E-5 | Systolic blood pressure;Diastolic blood pressure;Blood pressure |
| BLCA | cis | rs6951245 | 1 | rs113575110 | chr7:1084394 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.53 | 7.81E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs78153629 | 1 | rs113638727 | chr15:40706101 | C15orf23 | chr15:40674922-40686488:+ | 0.34 | 5.7 | 2.37E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs10935120 | 1 | rs1138273 | chr3:134261437 | ANAPC13 | chr3:134196547-134204865:- | 0.5 | 7.97 | 1.89E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs1138273 | chr3:134261437 | CEP63 | chr3:134204575-134293852:+ | 0.24 | 4.09 | 5.33E-5 | Height |
| BLCA | cis | rs6951245 | 1 | rs113858334 | chr7:1073476 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.31 | 2.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs9783347 | 1 | rs1140047 | chr11:18327684 | GTF2H1 | chr11:18343816-18388590:+ | 0.31 | 5.96 | 5.66E-9 | Pancreatic cancer |